WHAT WE DO:

• Molecular Biology

• Cell Biology and Fermentation

• Protein Production and Purification

• Assay Development and Screening

Biochemical assays for Multiple Targets

• Proven track record with kinases, phosphatases, proteases,lipid metabolic enzymes, epigenetic enzymes, ubiquitinautophagy and SUMO related enzymes,

• Ligand/receptor, DNA/protein and protein/protein interaction

Focused library screens and hit confirmation

Support project in Hit to Lead (H2L) and Lead Optimization (LO) Phases

Testing of H2L and LO compounds

• primary

• secondary

• selectivity/profiling assays

Support of Hit Validation

• Development of compound binding assays, thermal shift or other binding assays

• Studies of mechanism action for enzyme kinetics, compound reversibility